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Common Collagen Destroyers and How to Fight Them
Have you ever known someone who went through a difficult period that appeared to age them, almost overnight? Dark under-eye circles, a greyish complexion, worry lines and a more furrowed brow are all classic telltale signs of stress. But why do trying times end up being written all over our face? That is because cortisol, the infamous stress hormone, is a collagen degrader. Stress leads to wrinkles, skin dullness, dryness and loss of elasticity because cortisol causes progressive destruction of the collagen matrix that makes up 75% of healthy skin.1 Just a few weeks or even days of experimentally induced cortisol treatment can noticeably accelerate the appearance of skin aging due to collagen loss. 2
Another anti-collagen compound, one with much less notoriety and not stress-related, is homocysteine. Homocysteine is an amino acid, although not the helpful, muscle-building kind that we get from our diet. It is produced within the body and is normally eliminated with the help of certain B-vitamins. When levels of homocysteine build up, it increases the risk of heart disease and other health conditions. A simple blood test as part of your annual physical can check for elevated homocysteine. Left unchecked, high homocysteine levels interfere with normal, healthy collagen production.3
How to Protect Precious Collagen
BioSil® is a uniquely effective complex of choline and orthosilic acid (ch-OSA®) that activates the body’s production of collagen, elastin, and keratin. It’s patented ch-OSA® complex also protects existing collagen by lowering cortisol and homocysteine levels with choline. Choline is an essential B-vitamin-like nutrient that converts harmful homocysteine back into innocuous methionine. In doing so, BioSil® disarms a powerful collagen degrader. Emerging research suggests that the choline in BioSil® also helps to buffer some of the effects of stress.4
BioSil®‘s benefits are proven in unbiased, independent clinical studies conducted by leading European, American, and British university researchers. These studies are double-blind, placebo-controlled, and randomized. In other words, using the gold standards of scientific research, international scientists have documented statistically significant and clinically relevant results for hair, skin, nails, joints, and bones. Visit biosil.beauty to see the studies and learn more.
1 Choi D, Kang W, Park S, Son B, Park T. β-Ionone Attenuates Dexamethasone-Induced Suppression of Collagen and Hyaluronic Acid Synthesis in Human Dermal Fibroblasts. Biomolecules. 2021;11(5):619. Published 2021 Apr 21. doi:10.3390/biom11050619
2 Gebhardt, C., Averbeck, M., Diedenhofen, N., Willenberg, A., Anderegg, U., Sleeman, J. P., & Simon, J. C. (2010). Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids. The Journal of investigative dermatology, 130(1), 141–149. https://doi.org/10.1038/jid.2009.210
3 Thaler R, Agsten M, Spitzer S, et al. Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation. J Biol Chem. 2011;286(7):5578-5588. doi:10.1074/jbc.M110.166181
4 Bjelland I, Tell GS, Vollset SE, Konstantinova S, Ueland PM. Choline in anxiety and depression: the Hordaland Health Study. Am J Clin Nutr. 2009;90(4):1056-1060.